Benefits of drinking dissolved oxygenated water for older dogs

表題：高齢犬に対するペット用酸素補給水の有効性（和訳：QOLサポート研究会）

Mitsuhiro Isaka1 and Yutaro Suzuki2

1Department of Small Animal Clinical Sciences, School of Veterinar Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan
2WaterO, Inc, ANNEX101 1-33-5, Koyamadai, Shinagawa-ku, Tokyo 142-0061, Japan

Introduction

oxidative phosphorylation; therefore, must be reliably supplied to all metabolically active cells in the body [1, 2]. Hemoglobin is the primary carrier of oxygen in mammals. Approximately 98% of oxygen transport in the blood is hemoglobin-bound(bound oxygen), and only 2% is directly dissolved in plasma(dissolved oxygen) [3]. Coupled oxygen is primarily inoculated by pulmonary respiration and is thought to have a large molecular weight, preventing sufficient oxygen from reaching the capillaries [4, 5]. In contrast, dissolved oxygen is mainly absorbed through the gastrointestinal tract, and since it is in a gaseous state, its molecular weight is small and it can reach every corner of the capillaries (microcirculation) [6, 7].

Owing to the importance of oxygen supply, artificial oxygen carriers and other devices have also been studied in various pathological conditions; however, their clinical application is still lacking [8, 9].

In general, oxygen taken by breathing under atmospheric pressure cannot carry more than a certain amount of oxygen to the body, and in hyperbaric environments using Henry’s law, oxygen dissolves in the blood in proportion to the atmospheric pressure, allowing it to spread to every corner of the cell [10]. Local oxygen concentration is important, as it promotes metabolism, improves physical functions, activates the brain, promotes blood circulation (improves microcirculation), and prevents aging [11]. In the veterinary medical field, hyperbaric oxygen therapy has been reported for the treatment of bone fractures; however, there have J Vet Heal Sci, 2021 Volume 2 | Issue 1 | 20www.opastonline.com been few reports in dogs and cats as it is difficult to use for general purposes because of the cost and other factors. Moreover, it is not indicated in cases of underlying diseases, such as those of the heart [12].

Hypoxia and old age are closely related, and blood lactate rises in hypoxia, which has been reported as a prognostic factor for various diseases [11, 13]. However, there are no reports on the effects of dissolved oxygen supply in healthy old dogs. In recent times, high-performance liposome technology has enabled the dissolution and stabilization of oxygen in water so that oxygen can be absorbed from the gastrointestinal tract, allowing efficient delivery of oxygen to the terminal cellular level [14]. This study aimed to investigate whether or not oxygenated water (commercial: Water O, Inc, Tokyo, Japan) reduced serum lactate levels in old dogs.

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